Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome RUNNING TITLE: COOPERATIVE LOSS OF MIR-145 AND RPS14 IN 5Q- MDS

1 Koch Institute for Integrative Cancer Research, Department of Biology, and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA; 2 Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA; 3 Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; 4 Department of Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA; 5 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; 6 St. Vincent's Comprehensive Cancer Center, New York, New York 10011, USA; 7 Division of Hematology/Oncology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; 8 Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA; 9 Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA